Intended for Healthcare Professionals

genex^® Bone Graft Substitute

genex ^® Bone Graft Substitute is a simple to use synthetic absorbable material designed to promote regeneration of bone in osseous defects.

Overview System Features Specifications Education Videos Additional Information

Complements the body's natural healing processes and encourages normal bone structure

Unrivaled flexibility for delivery and application

Completely absorbs to leave no trace

In 12 months, genex is completely absorbed and remodeled while leaving no foreign artifacts after resorption^1,2

Biphasic composite of purity, balance, and characteristics

Our proprietary recrystallization and purification methods removes impurities from genex such as⁶

No inflammatory pyrophosphates
No slow and non-absorbing compounds such as hydroxyapatite

Several studies have concluded healthy bone is restored in a clinically relevant timeframe^7-9

genex is a precisely balanced ß tricalcium phosphate/calcium sulfate hemihydrate compound with distinct design properties:

Contains no hydroxyapatite (HA)
Negatively charged surface chemistry
Compressive strength similar to trabecular bone

Negatively charged genex enhances the osteogenic response to accelerate bone growth^10,14

genex containts no hydroxyapatite.
HA can only be absorbed at 1-2% per year¹²
up to 5 times normal levels (on the image):
In-vitro human osteoblast culture, 3 days¹¹

System Features

Unrivaled flexibility of delivery and application
Closed-mixing system is 2x faster to prepare than open mixing system¹³
Longer working time
Drillable 15 minutes after mixing

Specifications

Education

genex^® Bone Graft Substitute Brochure Preparation Guidelines

genex^® Bone Graft Substitute Brochure

genex^® Bone Graft Substitute Flyer

Videos

Click to play video

genex® Trailer

1 Min Watch

Additional Information

Yang HL et al. Bone healing response to a synthetic calcium sulfate/ß-tricalcium phosphate graft material in a sheep vertebral body defect model. J Biomed Mater Res B Appl Biomater 2012;100B(7):1911–21.
Clinical case study: Mr A Nisar and Mr S Gopal; Proximal femur fracture, Data on file.
Biocomposites internal testing: Biomaterials Compressive strength; Applicable methodology ISO/DIS 18531:2015(E) Implant for surgery – Calcium phosphate bioceramics – Characterization of hardening bone paste materials. 2015, MA0390R1.
Misch CE, Qu Z, Bidez MW. Mechanical properties of trabecular bone in the human mandible: implications for dental implant treatment planning and surgical placement. J Oral Maxillofac Surg. 1999 Jun;57(6):700 6; discussion 706-8. doi: 10.1016/s02782391(99)90437-8. PMID: 10368096
Dunham CE, Takaki SE, Johnson JA, Dunning CE. Mechanical properties of cancellous bone of the distal humerus. Clin Biomech (Bristol, Avon). 2005 Oct;20(8):834-8. doi: 10.1016/j. clinbiomech.2005.05.014. PMID: 16023773.
Biocomposites internal and external testing: genex Bone Graft Substitute technical file: Section 3.1.7 (Rev1) Final product specification, 2022.
Clinical case study: Mr HK Sharma; Tibial plateau fracture: Data on file.
Clinical case study: Prof JB Richardson; Distal tibia non-union: Data on file.
Clinical case study: Mr P Thompson; Single stage revision ACL reconstruction: Data on file.
Cooper JJ et al. Enhancing the osteogenic potential of bioabsorbable implants through control of surface charge. Presented at the Society for Biomaterials 2007 Annual Meeting, April, 2007: Chicago, Illinois, USA.
J J Cooper, J A Hunt., The Significance of Zeta Potential in Osteogenesis. Poster presented at Society for Biomaterials 2006 Annual Meeting, Pennsylvania, USA.
Pina S, Ferreira JMF. Bioresorbable plates and screws for clinical applications: A review. J Healthcare Engineering 2012;3(2):243–60.
Biocomposites internal and external testing: genex Bone Graft Substitute technical file: section 4.5.1.28 genex Bone Graft Substitute usability time evaluation study, 2022.
14. Stein JM, Fickl S, Yekta SS, et al. Clinical Evaluation of a Biphasic Calcium Composite Grafting Material in the Treatment of Human Periodontal Intrabony Defects: A 12-Month Randomized Controlled Clinical Trial. J Periodontol. 2009 Nov; 80 (11): 1774-82. doi: 10.1902/jop.2009.090229.

Dry26™ genex™ are trademarks of Biocomposites, LTD

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For product information, including indications, contraindications, warnings, precautions, potential adverse effects and patient counseling information, see the package insert or contact your local representative; search this website for additional product information. To obtain a copy of the current Instructions for Use (IFU) for full prescribing and risk information, please visit labeling.zimmerbiomet.com or call 1-800-348-2759, press 4 for 411 Technical Support.

genex^® Bone Graft Substitute

Complements the body's natural healing processes and encourages normal bone structure